Long-Term Effectiveness of Polymerized-Type I Collagen Intra-Articular Injections in Patients with Symptomatic Knee Osteoarthritis: Clinical and Radiographic Evaluation in a Cohort Study.

OBJECTIVE: Polymerized-type I collagen (polymerized-collagen) is a downregulator of inflammation and a tissue regenerator. The aim was to evaluate the effect of intra-articular injections (IAIs) of polymerized-collagen among patients with symptomatic knee osteoarthritis (OA) in delaying or preventing joint replacement surgery. Patients and Methods. This was a cohort study of 309 patients with knee OA. Patients with mild-to-moderate disease were treated weekly with IAIs of 2 mL of polymerized-collagen for six weeks (n = 309). Follow-up was for 6-60 months. The primary endpoints included the following determinations: (1) therapeutic effect; (2) survival from total knee replacement surgery (TKR); (3) Western Ontario and McMaster University Osteoarthritis Index (WOMAC) and pain (visual analogue scale, VAS). Clinical improvement was defined as a decrease in pain exceeding 20 mm on the VAS and the achievement of at least 20% improvement from baseline with respect to the WOMAC score. Radiographic analysis was performed at baseline and 60 months. The joint space width in the medial, lateral, and patellofemoral compartments was calculated. RESULTS: Patients who received IAIs of polymerized-collagen had a statistically significant improvement in the primary criteria (p < 0.05). Kaplan-Meier survival analysis of the therapeutic effect demonstrated 98.8% survival at 60 months with TKR as the endpoint. There was no significant reduction in joint space in any compartment based on the analyzed radiographs. No serious adverse events were recorded. CONCLUSION: Polymerized-collagen increased the time to TKR by at least 60 months, modifying the disease course, improving functional disability, and decreasing pain.

Proyecto de atención comunitaria a la poblacion anciana de Cuernavaca, Morelos: Resultados tercera fase: 10.000 ancianos / Community care for the Cuernavaca, Morelos' elder population project: Phase results 3: 10,000 elderlies

El trabajo presenta la métodologia empleada, los resultados y el reporte preliminar de una encuesta auspiciada por la Organización Panamericana de la Salud y llevada a cabo en 3 fases, durante 9 meses en el Municipio de Cuernavaca, Estado de Morelos, en la que se entrevistaron 10.000 ancianos. Incluye aspectos demograficos y socioeconómicos, informacion sobre las condiciones de salud, descripcion del sistema gubernamental de servicios de salud en la ciudad de Cuernavaca, y de los servicios de la Casa-Hogar para Ancianos "Olga Tamayo"

Proyecto de atención comunitaria a la población anciana de Cuernavaca, Morelos : Resultados tercera fase : 10.000=diez mil ancianos / Community care for the Cuernavaca, Morelos' elder population project : Phase results

El trabajo presenta la metodología empleada, los resultados y el reporte preliminar de una encuesta auspiciada por la Organización Panamericana de la Salud y llevada a cabo en 3 fases, durante 9 meses en el Municipio de Cuernavaca, Estado de Morelos, en la que se entrevistaron 10.000 ancianos. Incluye aspectos demográficos y socioeconómicos, información sobre las condiciones de salud, descripción del sistema gubernamental de servicios de salud en la ciudad de Cuernavaca, y de los servicios de la Casa-Hogar para Ancianos "Olga Tamayo"